For much of the design work that I do, I prefer to work in the metric system. Once you're in CAD, it is just a number, the system you're using, imperial or Metric doesn't mean much.
For engineering calculations involving force, distance, torque, thermal units, etc, it is far easier to use the Metric system. I can remember in engineering school having complex problems in the imperial system. We would convert the inputs to the metric system (easy conversion), do the problem in metric, and then convert the answer back to imperial.
About the only "advantage" for the imperial system is when working with 2x lumber in the house building sector.... outside of that, I prefer the metric system.
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